Effect of (xeno)-estrogens on zebrafish P450c17 (C17, 17 alpha-hydroxylase/17, 20-lyase) mRNA and protein expression in gonadal tissue - Ineris - Institut national de l'environnement industriel et des risques Access content directly
Journal Articles Cybium : Revue Internationale d’Ichtyologie Year : 2008

Effect of (xeno)-estrogens on zebrafish P450c17 (C17, 17 alpha-hydroxylase/17, 20-lyase) mRNA and protein expression in gonadal tissue

Abstract

The objectives of this study were to determine the expression and the cellular localization of P450c17 in gonadal tissues in the zebrafish and to investigate the effect of (xeno)-hormones on its expression at both mRNA and protein levels. We showed that gonads are sites for cyp17 gene expression and we documented for the first time the cellular localization of the cyp17 protein expression within ovarian and testicular tissues in a cyprinid fish. Moreover, we demonstrated the down-regulating effect of (xeno)-estrogens on testicular cyp17 expression.
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Dates and versions

ineris-00963150 , version 1 (21-03-2014)

Identifiers

  • HAL Id : ineris-00963150 , version 1
  • INERIS : EN-2008-067

Cite

François Brion, Nathalie Hinfray, Olivier Palluel, Julien Maillard, Isabelle Anglade, et al.. Effect of (xeno)-estrogens on zebrafish P450c17 (C17, 17 alpha-hydroxylase/17, 20-lyase) mRNA and protein expression in gonadal tissue. Cybium : Revue Internationale d’Ichtyologie, 2008, 32 (2, suppl. S), pp.245-246. ⟨ineris-00963150⟩
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