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Book Sections Year : 2011

Oral bioavailability

Abstract

Soil ingestion is a key exposure pathway in Human Health Risk Assessment for contaminants in soil. The theory and mechanisms of how contaminants in a soil enter the human body through the gastrointestinal tract are outlined. The methods available for measuring human exposure using human, animal and validated in-vitro laboratory methods are described and contrasted. The role of the physico-chemical properties of the soils that control the bioavailability of contaminants are summarised. Finally, examples of how bioavailability/bioaccessibility studies of soils from both anthropogenic and geogenic origin are discussed along with the criteria required for deciding whether bioavailability data should be used in a Human Health Risk Assessment.
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Dates and versions

ineris-00969439 , version 1 (02-04-2014)

Identifiers

  • HAL Id : ineris-00969439 , version 1
  • INERIS : EN-2011-370

Cite

Mark Cave, Joanna Wragg, Sébastien Denys, Catherine Jondreville, Cyril Feidt. Oral bioavailability. SWARTJES, Frank A. Dealing with contaminated sites. From theory towards practical application, Springer. Dordrecht, pp.287-324, 2011, Earth and Environmental Science. ⟨ineris-00969439⟩
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