Longitudinal 3He and proton imaging of magnetite biodistribution in a rat model of instilled nanoparticles - Ineris - Institut national de l'environnement industriel et des risques Access content directly
Journal Articles Magnetic Resonance in Medicine Year : 2008

Longitudinal 3He and proton imaging of magnetite biodistribution in a rat model of instilled nanoparticles

Abstract

Epidemiological and toxicological studies have provided evidence that accidentally inhaled nanosize ultrafine particles can induce chronic or acute health damage. MRI, being noninvasive, is able to assess the biodistribution and clearance of magnetically labeled nanoparticles induced by instillation or inhalation. We report He-3 and proton MRI follow-up of lung, liver, spleen, and kidney distribution of USPIO (ultrasmall superparamagnetic iron oxide) in a rat model. The sensitivity of the imaging technique to various concentrations of instilled magnetite suspension was first assessed in vivo (n = 12). A 2-week longitudinal imaging study was then performed on animals (n = 7) instilled with a 0.5 mg magnetite solution. Hypointense and void signal regions associated with intrapulmonary USPIO were observed in the He-3 ventilation images throughout the study, whereas no USPIO-related proton signal intensity changes were found. Intrapulmonary magnetite nanoparticle confinement was confirmed by ex vivo iron assay and histological analysis. This study demonstrates that combined 3 He and proton MRI enables noninvasive assessment of the distribution and clearance of magnetically labeled instilled nanoparticles

Dates and versions

ineris-00963121 , version 1 (21-03-2014)

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Achraf Al Faraj, Ghislaine Lacroix, Hasan Alsaid, Dan Elgrabli, Vasile Stupar, et al.. Longitudinal 3He and proton imaging of magnetite biodistribution in a rat model of instilled nanoparticles. Magnetic Resonance in Medicine, 2008, 59 (6), pp.1298-1303. ⟨10.1002/mrm.21571⟩. ⟨ineris-00963121⟩
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