Physiologically-based kinetic modelling (PBK modelling) : meeting the 3Rs agenda - Ineris - Institut national de l'environnement industriel et des risques Access content directly
Journal Articles ATLA - Alternatives to Laboratory Animals Year : 2007

Physiologically-based kinetic modelling (PBK modelling) : meeting the 3Rs agenda

David E. Leahy
  • Function : Author
Jiansong Yang
  • Function : Author


This is the report of the 63rd of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM's main objective, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are relevant to the biosciences and which reduce, refine or replace the use of laboratory animals. One of the first priorities set by ECVAM was the implementation of procedures that would permit the acquisition of expertise about the state of-the-art of on-animal test development and validation, and the potential for incorporating such alternative tests into regulatory procedures. It was decided that this would be best achieved through a programme of ECVAM workshops, each addressing a specific topic, and at which selected groups of independent international experts would review the current status of various types of in vitro tests and their potential uses, and make recommendations about the best ways forward.
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Dates and versions

ineris-00963095 , version 1 (21-03-2014)


  • HAL Id : ineris-00963095 , version 1
  • INERIS : EN-2008-008
  • PUBMED : 18186671


Michel Bouvier d'Yvoire, Pilar Prieto, Bas J. Blaauboer, Frédéric Y. Bois, Alan Boobis, et al.. Physiologically-based kinetic modelling (PBK modelling) : meeting the 3Rs agenda. ATLA - Alternatives to Laboratory Animals, 2007, 35 (6), pp.661-671. ⟨ineris-00963095⟩


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