Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog - Plateforme RMN - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2020

Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog

Jérôme Guillard
  • Fonction : Auteur
Jerome Desire
Yves Blériot

Résumé

A new family of chiral C2 symmetric tetraazamacrocycles, coined ISAC for IminoSugar Aza-Crown, incorporating two iminosugars adopting a 4C1 conformation is disclosed. Multinuclear NMR experiments on the corresponding Cd2+ complex show that the ISAC is a strong chelator in water and its tetramine cavity adopts a conformation similar to that of the parent Cd–cyclam complex. Similar behavior is observed with Cu2+ in solution, with enhanced stability compared to the Cu–cyclam complex.
Fichier principal
Vignette du fichier
ol0c00503.pdf (2.22 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02504835 , version 1 (12-04-2024)

Identifiants

Citer

Alexandra Bordes, Ana Poveda, Thibault Troadec, Antonio Franconetti, Ana Arda, et al.. Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog. Organic Letters, 2020, 22 (6), pp.2344-2349. ⟨10.1021/acs.orglett.0c00503⟩. ⟨hal-02504835⟩
164 Consultations
4 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More