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Structure: Internal structure identifier : 537403
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Development of a lung-liver in vitro coculture model for the risk assessment of inhaled xenobiotics

Sabrina Madiedo-Podvršan
Bioengineering. Université de Technologie de Compiègne, 2022. English. ⟨NNT : 2022COMP2703⟩
Theses tel-04145169v1

Determination of absorption and biotransformation of benzo[a]pyrene in a perfusion co-culture system for physiologically based pharmacokinetics models

Djomangan Adama Ouattara , S. Choi , Y. Sakai , Céline Brochot
12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain
Conference papers ineris-00970651v1

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

Régis Baudoin , Jean-Matthieu Prot , Grégory Nicolas , Jessy Brocheton , Céline Brochot , et al.
Xenobiotica, 2013, 43 (2), pp.140-152. ⟨10.3109/00498254.2012.706725⟩
Journal articles ineris-00963431v1
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Modélisation de la toxicocinétique des isomères cis et trans de la perméthrine et de ses métabolites chez le rat et de leur métabolisme sur hépatocytes humains

Marie-Émilie Willemin
Biomécanique [physics.med-ph]. Université de Technologie de Compiègne, 2014. Français. ⟨NNT : 2014COMP2149⟩
Theses tel-01127586v1
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Bioinformatic and modelling approaches for a system-level understanding of oxidative stress toxicity

Elias Zgheib
Quantitative Methods [q-bio.QM]. Université de Technologie de Compiègne, 2018. English. ⟨NNT : 2018COMP2464⟩
Theses tel-02088169v1

Liver-kidney microfluidic bioreactor for cell co-culture in drug studies

L. Choucha Snouber , Laurent Griscom , Pe Poleni , Florence Razan , Céline Brochot , et al.
MICROTAS, Oct 2010, GRONINGEN, Netherlands. pp.0328
Conference papers hal-00756580v1
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Capacité de modèles in vitro de complexité différente à prédire les réponses toxiques pulmonaires observées in vivo après exposition aiguë à des nanoparticules de TiO2 et de CeO2

Thomas Loret
Biomécanique [physics.med-ph]. Université de Technologie de Compiègne, 2017. Français. ⟨NNT : 2017COMP2358⟩
Theses tel-01630236v1

High-throughput methods for toxicology and health risk assessment

Elias Zgheib , Camille Béchaux , Amélie Crépet , Enrico Mombelli , Frédéric Y. Bois
Environnement, Risques & Santé, 2017, 16 (1), pp.44-58. ⟨10.1684/ers.2016.0943⟩
Journal articles ineris-01853562v1
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Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods

Thomas Loret , Françoise Rogerieux , Bénédicte Trouiller , Anne Braun , Christophe Egles , et al.
Particle and Fibre Toxicology, 2018, 15, pp.25. ⟨10.1186/s12989-018-0260-6⟩
Journal articles ineris-01863341v1
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PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats

Marie-Emilie Willemin , Sophie Desmots , Rozenn Le Grand , François Lestremau , Florence Anna Zeman , et al.
Toxicology and Applied Pharmacology, 2016, 294, pp.65-77. ⟨10.1016/j.taap.2016.01.011⟩
Journal articles ineris-01862928v1
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A mechanistic modeling framework for predicting metabolic interactions in complex mixtures

Shu Cheng , Frédéric Y. Bois
Environmental Health Perspectives, 2011, 119 (12), pp.1712-1718. ⟨10.1289/ehp.1103510⟩
Journal articles ineris-00961768v1

Elaboration d'un modèle toxicocinétique de la cis et trans-perméthrine et de ses métabolites chez le rat

Marie-Emilie Willemin , Sophie Desmots , Rozenn Le Grand , Florence Anna Zeman , François Lestremau , et al.
5. journées internationales de toxicologie, Oct 2013, Liège, Belgium
Conference papers ineris-00971203v1

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

Jean-Matthieu Prot , Luis Maciel , Thibault Bricks , Franck Merlier , Jérôme Cotton , et al.
Biotechnology and Bioengineering, 2014, 111 (10), pp.2027-2040. ⟨10.1002/bit.25232⟩
Journal articles istex ineris-01855015v1

Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs

Laetitia Shintu , Régis Baudoin , Vincent Navratil , Jean-Matthieu Prot , Clément Pontoizeau , et al.
Analytical Chemistry, 2012, 84 (4), pp.1840-1848. ⟨10.1021/ac2011075⟩
Journal articles hal-00699575v1
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Application of three approaches for quantitative AOP development to renal toxicity

Elias Zgheib , Wang Gao , Alice Limonciel , Hristo Aladjov , Huan Yang , et al.
Computational Toxicology, 2019, 11, pp.1-13. ⟨10.1016/j.comtox.2019.02.001⟩
Journal articles hal-02987394v1

Kinetic modelling of in vitro cell-based assays to characterize non-specific bindings and ADME processes in a static and a perfused fluidic system

Djomangan Adama Ouattara , Sue-Hyung Choi , Yasuyuki Sakai , Alexandre R.R. Pery , Céline Brochot
Toxicology Letters, 2011, 205 (3), pp.310-319. ⟨10.1016/j.toxlet.2011.06.021⟩
Journal articles istex ineris-00963306v1

Pharmaco-metabonomic investigation of acetaminophen toxicity on rat primary hepatocytes in microfluidic biochips

Claire Lopez , Mathilde Bayet-Robert , Marc-Emmanuel Dumas , Jean-Matthieu Prot , Alexandre R.R. Pery , et al.
7e Journées scientifiques du Réseau Français de Métabolomique et Fluxomique (RFMF), Jun 2013, Amiens, France
Conference papers hal-00980023v1

Toxicologie predictive: les voies du futur

Ph Detilleux , L Vallier , C Legallais , E Leclerc , M Prot J , et al.
Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France
Conference papers hal-01122677v1

Integration of pharmacokinetic and NRF2 system biology models to describe reactive oxygen species production and subsequent glutathione depletion in liver microfluidic biochips after flutamide exposure

Eric Leclerc , Jeremy Hamon , Audrey Legendre , Frédéric Y. Bois
Toxicology in Vitro, 2014, 28 (7), pp.1230-1241. ⟨10.1016/j.tiv.2014.05.003⟩
Journal articles ineris-01855016v1

Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver–kidney microfluidic data and pharmacokinetic-system biology models

Eric Leclerc , Jeremy Hamon , Frédéric Y. Bois
Journal of Applied Toxicology, 2016, 36 (2), pp.330-339. ⟨10.1002/jat.3191⟩
Journal articles istex ineris-01854099v1
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Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions

Thomas Loret , Emmanuel Peyret , Marielle Dubreuil , Olivier Aguerre-Chariol , Christophe Bressot , et al.
Particle and Fibre Toxicology, 2016, 13, pp.art. 58. ⟨10.1186/s12989-016-0171-3⟩
Journal articles ineris-01863163v1

Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells

Djomangan Adama Ouattara , Jean-Matthieu Prot , Andrei Bunescu , Marc-Emmanuel Dumas , Bénédicte Elena-Herrmann , et al.
Molecular BioSystems, 2012, 8 (7), pp.1908-1920. ⟨10.1039/c2mb25049g⟩
Journal articles ineris-00963393v1

Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models

Thibault Bricks , Jeremy Hamon , Marie José Fleury , Rachid Jellali , Franck Merlier , et al.
Biopharmaceutics and Drug Disposition, 2015, 36 (5), pp.275-293. ⟨10.1002/bdd.1940⟩
Journal articles istex ineris-01855074v1

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.

Leila Choucha-Snouber , Caroline Aninat , Laurent Grsicom , Geoffrey Madalinski , Céline Brochot , et al.
Biotechnology and Bioengineering, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩
Journal articles istex inserm-00864839v1
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Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

Elias Zgheib , Alice Limonciel , Xiaoqi Jiang , Anja Wilmes , Steven Wink , et al.
Frontiers in Genetics, 2018, 9, pp.art. 429. ⟨10.3389/fgene.2018.00429⟩
Journal articles ineris-03319036v1
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Determination of cis-permethrin, trans-permethrin and associated metabolites in rat blood and organs by gas chromatography–ion trap mass spectrometry

Francois Lestremau , Marie-Emilie Willemin , Claudine Chatellier , Sophie Desmots , Céline Brochot
Analytical and Bioanalytical Chemistry, 2014, 406 (14), pp.3477-3487. ⟨10.1007/s00216-014-7774-z⟩
Journal articles ineris-01710209v1

In vitro human metabolism of permethrin isomers alone or as a mixture and the formation of the major metabolites in cryopreserved primary hepatocytes

Marie-Emilie Willemin , Ali Kadar , Georges de Sousa , E. Leclerc , Roger Rahmani , et al.
Toxicology in Vitro, 2015, 29 (4), pp.803-812. ⟨10.1016/j.tiv.2015.03.003⟩
Journal articles ineris-01855035v1

Investigation of acetaminophen toxicity in HepG2/ C3a microscale cultures using a system biology model of glutathione depletion

Eric Leclerc , Jeremy Hamon , Isabelle Claude , Rachid Jellali , Marie Naudot , et al.
Cell Biology and Toxicology, 2015, 31 (3), pp.173-185. ⟨10.1007/s10565-015-9302-0⟩
Journal articles ineris-01855075v1
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Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions

Shu Cheng , Jean-Matthieu Prot , Eric Leclerc , Frédéric Y. Bois
BMC Genomics, 2012, 13, pp.art. 54. ⟨10.1186/1471-2164-13-54⟩
Journal articles ineris-00961774v1

Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips

Leila Choucha-Snouber , Andrei Bunescu , Cécile Legallais , Céline Brochot , Marc-Emmanuel Dumas , et al.
Toxicological Sciences, 2013, 132 (1), pp.8-20. ⟨10.1093/toxsci/kfs230⟩
Journal articles ineris-00963445v1