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Development of a lung-liver in vitro coculture model for the risk assessment of inhaled xenobiotics
Sabrina Madiedo-Podvršan
Theses
tel-04145169v1
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Determination of absorption and biotransformation of benzo[a]pyrene in a perfusion co-culture system for physiologically based pharmacokinetics models
Djomangan Adama Ouattara
,
S. Choi
,
Y. Sakai
,
Céline Brochot
12. International Congress of Toxicology (IUTOX 2010), Jul 2010, Barcelone, Spain
Conference papers
ineris-00970651v1
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Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips
Régis Baudoin
,
Jean-Matthieu Prot
,
Grégory Nicolas
,
Jessy Brocheton
,
Céline Brochot
,
et al.
Journal articles
ineris-00963431v1
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Modélisation de la toxicocinétique des isomères cis et trans de la perméthrine et de ses métabolites chez le rat et de leur métabolisme sur hépatocytes humains
Marie-Émilie Willemin
Biomécanique [physics.med-ph]. Université de Technologie de Compiègne, 2014. Français. ⟨NNT : 2014COMP2149⟩
Theses
tel-01127586v1
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Bioinformatic and modelling approaches for a system-level understanding of oxidative stress toxicity
Elias Zgheib
Quantitative Methods [q-bio.QM]. Université de Technologie de Compiègne, 2018. English. ⟨NNT : 2018COMP2464⟩
Theses
tel-02088169v1
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Liver-kidney microfluidic bioreactor for cell co-culture in drug studies
L. Choucha Snouber
,
Laurent Griscom
,
Pe Poleni
,
Florence Razan
,
Céline Brochot
,
et al.
MICROTAS, Oct 2010, GRONINGEN, Netherlands. pp.0328
Conference papers
hal-00756580v1
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Capacité de modèles in vitro de complexité différente à prédire les réponses toxiques pulmonaires observées in vivo après exposition aiguë à des nanoparticules de TiO2 et de CeO2
Thomas Loret
Biomécanique [physics.med-ph]. Université de Technologie de Compiègne, 2017. Français. ⟨NNT : 2017COMP2358⟩
Theses
tel-01630236v1
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High-throughput methods for toxicology and health risk assessment
Elias Zgheib
,
Camille Béchaux
,
Amélie Crépet
,
Enrico Mombelli
,
Frédéric Y. Bois
Journal articles
ineris-01853562v1
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Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods
Thomas Loret
,
Françoise Rogerieux
,
Bénédicte Trouiller
,
Anne Braun
,
Christophe Egles
,
et al.
Journal articles
ineris-01863341v1
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PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats
Marie-Emilie Willemin
,
Sophie Desmots
,
Rozenn Le Grand
,
François Lestremau
,
Florence Anna Zeman
,
et al.
Journal articles
ineris-01862928v1
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A mechanistic modeling framework for predicting metabolic interactions in complex mixtures
Shu Cheng
,
Frédéric Y. Bois
Journal articles
ineris-00961768v1
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Elaboration d'un modèle toxicocinétique de la cis et trans-perméthrine et de ses métabolites chez le rat
Marie-Emilie Willemin
,
Sophie Desmots
,
Rozenn Le Grand
,
Florence Anna Zeman
,
François Lestremau
,
et al.
5. journées internationales de toxicologie, Oct 2013, Liège, Belgium
Conference papers
ineris-00971203v1
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First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans
Jean-Matthieu Prot
,
Luis Maciel
,
Thibault Bricks
,
Franck Merlier
,
Jérôme Cotton
,
et al.
Journal articles
istex
ineris-01855015v1
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Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs
Laetitia Shintu
,
Régis Baudoin
,
Vincent Navratil
,
Jean-Matthieu Prot
,
Clément Pontoizeau
,
et al.
Journal articles
hal-00699575v1
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Application of three approaches for quantitative AOP development to renal toxicity
Elias Zgheib
,
Wang Gao
,
Alice Limonciel
,
Hristo Aladjov
,
Huan Yang
,
et al.
Journal articles
hal-02987394v1
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Kinetic modelling of in vitro cell-based assays to characterize non-specific bindings and ADME processes in a static and a perfused fluidic system
Djomangan Adama Ouattara
,
Sue-Hyung Choi
,
Yasuyuki Sakai
,
Alexandre R.R. Pery
,
Céline Brochot
Journal articles
istex
ineris-00963306v1
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Pharmaco-metabonomic investigation of acetaminophen toxicity on rat primary hepatocytes in microfluidic biochips
Claire Lopez
,
Mathilde Bayet-Robert
,
Marc-Emmanuel Dumas
,
Jean-Matthieu Prot
,
Alexandre R.R. Pery
,
et al.
7e Journées scientifiques du Réseau Français de Métabolomique et Fluxomique (RFMF), Jun 2013, Amiens, France
Conference papers
hal-00980023v1
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Toxicologie predictive: les voies du futur
Ph Detilleux
,
L Vallier
,
C Legallais
,
E Leclerc
,
M Prot J
,
et al.
Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France
Conference papers
hal-01122677v1
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Integration of pharmacokinetic and NRF2 system biology models to describe reactive oxygen species production and subsequent glutathione depletion in liver microfluidic biochips after flutamide exposure
Eric Leclerc
,
Jeremy Hamon
,
Audrey Legendre
,
Frédéric Y. Bois
Journal articles
ineris-01855016v1
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Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver–kidney microfluidic data and pharmacokinetic-system biology models
Eric Leclerc
,
Jeremy Hamon
,
Frédéric Y. Bois
Journal articles
istex
ineris-01854099v1
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Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions
Thomas Loret
,
Emmanuel Peyret
,
Marielle Dubreuil
,
Olivier Aguerre-Chariol
,
Christophe Bressot
,
et al.
Journal articles
ineris-01863163v1
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Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells
Djomangan Adama Ouattara
,
Jean-Matthieu Prot
,
Andrei Bunescu
,
Marc-Emmanuel Dumas
,
Bénédicte Elena-Herrmann
,
et al.
Journal articles
ineris-00963393v1
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Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models
Thibault Bricks
,
Jeremy Hamon
,
Marie José Fleury
,
Rachid Jellali
,
Franck Merlier
,
et al.
Journal articles
istex
ineris-01855074v1
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Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.
Leila Choucha-Snouber
,
Caroline Aninat
,
Laurent Grsicom
,
Geoffrey Madalinski
,
Céline Brochot
,
et al.
Journal articles
istex
inserm-00864839v1
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Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases
Elias Zgheib
,
Alice Limonciel
,
Xiaoqi Jiang
,
Anja Wilmes
,
Steven Wink
,
et al.
Journal articles
ineris-03319036v1
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Determination of cis-permethrin, trans-permethrin and associated metabolites in rat blood and organs by gas chromatography–ion trap mass spectrometry
Francois Lestremau
,
Marie-Emilie Willemin
,
Claudine Chatellier
,
Sophie Desmots
,
Céline Brochot
Journal articles
ineris-01710209v1
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In vitro human metabolism of permethrin isomers alone or as a mixture and the formation of the major metabolites in cryopreserved primary hepatocytes
Marie-Emilie Willemin
,
Ali Kadar
,
Georges de Sousa
,
E. Leclerc
,
Roger Rahmani
,
et al.
Journal articles
ineris-01855035v1
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Investigation of acetaminophen toxicity in HepG2/ C3a microscale cultures using a system biology model of glutathione depletion
Eric Leclerc
,
Jeremy Hamon
,
Isabelle Claude
,
Rachid Jellali
,
Marie Naudot
,
et al.
Journal articles
ineris-01855075v1
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Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions
Shu Cheng
,
Jean-Matthieu Prot
,
Eric Leclerc
,
Frédéric Y. Bois
Journal articles
ineris-00961774v1
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Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips
Leila Choucha-Snouber
,
Andrei Bunescu
,
Cécile Legallais
,
Céline Brochot
,
Marc-Emmanuel Dumas
,
et al.
Journal articles
ineris-00963445v1
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