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Identification of genes regulated by the environmental contaminant benzo(a)pyrene in primary human macrophages
Lydie Sparfel
,
Marie-Laure Pinel-Marie
,
Magali Boize
,
Serge Koscielny
,
Sophie Desmots
,
et al.
Annual Meeting 100th American Association for Cancer Research, Apr 2009, Denver, United States
Conference papers
hal-00673940v1
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AhR-dependent induction of the NADPH oxidase component p47phox by benzo(a)pyrene in human macrophages
Marie-Laure Pinel-Marie
,
Lydie Sparfel
,
Sophie Desmots
,
Olivier Fardel
Annual Meeting 100th American Association for Cancer Research, Apr 2009, Denver, United States
Conference papers
hal-00674272v1
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Perturbateurs de la fonction endocrinienne et santé : un point non exhaustif sur les connaissances
Sophie Desmots
,
Catherine Brulez
,
Emmanuel Lemazurier
Environnement, Risques & Santé, 2005, 4 (3), pp.195-204
Journal articles
ineris-00962957v1
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Predicting in vivo gene expression in macrophages after exposure to benzo(a)pyrene based on in vitro assays and toxicokinetic/toxicodynamic models
Alexandre R.R. Pery
,
Céline Brochot
,
Sophie Desmots
,
Magali Boize
,
Lydie Sparfel
,
et al.
Journal articles
hal-00873317v1
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Modulation de la localisation cellulaire de la claudine 11 et de la p-glycoprotéine durant le développement postnatal chez le rat : mise en évidence d'un nouveau concept d'auto-défense du testicule immature et implication dans la barrière hémato-testiculaire
Audrey Legendre
,
Sophie Desmots
,
Anthony Lecomte
,
Franck Robidel
,
Olivier Dupont
,
et al.
Congrès de la SPTC. Sociétés de Pharmacologie-Toxicologie Cellulaire "Toxicologie Prédictive : les Voies du Futur", May 2010, Paris, France
Conference papers
ineris-00970621v1
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The in vitro blood-testis-barrier : a new promising alternative for reproductive toxicity studies
Audrey Legendre
,
Sophie Desmots
,
Anthony Lecomte
,
Pascal Froment
,
René Habert
,
et al.
2. International Conference on Innovation for Sustainable Production 2010 (I-SUP2010), May 2010, Bruges, Belgium
Conference papers
ineris-00970639v1
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Effects of endocrine disruptors on steroidogenic enzymes gene expression and on aromatase activity in two human cell lines
Nadia Quignot
,
Sophie Desmots
,
Robert Barouki
,
Emmanuel Lemazurier
92. Annual Meeting & Expo (ENDO 2010), Jun 2010, San Diego, United States
Conference papers
ineris-00970646v1
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Evaluation of Placental Transfer and Tissue Distribution of cis- and Trans-Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model
Stéphane Personne
,
Céline Brochot
,
Paulo Marcelo
,
Aurélie Corona
,
Sophie Desmots
,
et al.
Journal articles
ineris-03498668v1
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An engineered 3D blood-testis barrier model for the assessment of reproductive toxicity potential
Audrey Legendre
,
Pascal Froment
,
Sophie Desmots
,
Anthony Lecomte
,
René Habert
,
et al.
Journal articles
istex
ineris-00963581v1
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PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats
Marie-Emilie Willemin
,
Sophie Desmots
,
Rozenn Le Grand
,
François Lestremau
,
Florence Anna Zeman
,
et al.
Journal articles
ineris-01862928v1
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Substance-tailored testing strategies in toxicology : an in silico methodology based on QSAR modeling of toxicological thresholds and Monte Carlo simulations of toxicological testing
Alexandre R.R. Pery
,
Sophie Desmots
,
Enrico Mombelli
Journal articles
ineris-00961749v1
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L'évaluation des risques liés à une exposition aux Hydrocarbures Aromatiques Polycycliques (HAPs) : nouvelle approche
Magali Boize
,
Alexandre R.R. Pery
,
Sophie Desmots
,
Serge Koscielny
,
Lydie Sparfel
,
et al.
Colloque International francophone "Les hydrocarbures aromatiques polycycliques, de la recherche à la prévention", Sep 2008, Montréal, Canada
Conference papers
ineris-00970373v1
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Développement d'un modèle de barrière hemato-testiculaire (BHT) in vitro pour l'évaluation des reprotoxiques
Audrey Legendre
,
Sophie Desmots
,
Anthony Lecomte
,
Pascal Froment
,
René Habert
,
et al.
Congrès de la SPTC. Sociétés de Pharmacologie-Toxicologie Cellulaire "Toxicologie Prédictive : les Voies du Futur", May 2010, Paris, France
Conference papers
ineris-00970622v1
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The in vitro blood-testis-barrier : a new promising alternative for reproductive toxicity studies
Audrey Legendre
,
Sophie Desmots
,
Anthony Lecomte
,
Pascal Froment
,
René Habert
,
et al.
1. European Doctoral College on Environment and Health (EDCEH), Jun 2010, Rennes, France
Conference papers
ineris-00970640v1
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Elaboration d'un modèle toxicocinétique de la cis et trans-perméthrine et de ses métabolites chez le rat
Marie-Emilie Willemin
,
Sophie Desmots
,
Rozenn Le Grand
,
Florence Anna Zeman
,
François Lestremau
,
et al.
5. journées internationales de toxicologie, Oct 2013, Liège, Belgium
Conference papers
ineris-00971203v1
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Mise en place d'une barrière hémato-testiculaire in vitro comme méthode alternative et complémentaire à l'expérimentation animale pour l'étude des effets des perturbateurs de la fonction endocrinienne
Audrey Legendre
,
Sophie Desmots
,
Anthony Lecomte
,
Franck Robidel
,
Olivier Dupont
,
et al.
25. Congrès de la Société d'Andrologie de Langue Française (SALF 2008), Sep 2008, Hammamet, Maroc
Conference poster
ineris-00970396v1
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Endocrine disruption and steroidogenesis : integrated evaluation from gonadal steroidogenic enzymes in vitro and in vivo to hormonal balance and fertility assessment in vivo
Nadia Quignot
,
Sophie Desmots
,
Robert Barouki
,
Emmanuel Lemazurier
8. World Congress on Alternatives and Animal Use in the Life Sciences, Aug 2011, Montreal, Canada
Conference papers
ineris-00970887v1
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Development of alternative to animal methods for reproductive toxicity studies : An in vitro blood - testis - barrier
Audrey Legendre
,
Sophie Desmots
,
Anthony Lecomte
,
Franck Robidel
,
Olivier Dupont
,
et al.
7. World congress on alternatives and animal use in the life sciences, Aug 2009, Rome, Italy
Conference papers
ineris-00970502v1
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Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene.
Lydie Sparfel
,
Marie-Laure Pinel-Marie
,
Magali Boize
,
Serge Koscielny
,
Sophie Desmots
,
et al.
Journal articles
istex
hal-00657921v1
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Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcalphaRI by the environmental contaminant benzo(a)pyrene in human macrophages
Lydie Sparfel
,
Marie-Laure Pinel-Marie
,
L. Louarn
,
Sophie Desmots
,
Olivier Fardel
47. European Congress of Toxicology (EUROTOX 2011), Aug 2011, Paris, France
Conference papers
ineris-00970856v1
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Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data : A case study with acetaminophen
Alexandre R.R. Pery
,
Céline Brochot
,
Florence Anna Zeman
,
Enrico Mombelli
,
Sophie Desmots
,
et al.
Journal articles
ineris-00961804v1
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Intérêt potentiel de cibles géniques des hydrocarbures aromatiques polycycliques en tant que biomarqueurs d'exposition
Lydie Sparfel
,
Marie-Laure Pinel-Marie
,
Serge Koscielny
,
Sophie Desmots
,
Alexandre R.R. Pery
,
et al.
Environnement, Risques & Santé, 2011, 10 (3), pp.195-199
Journal articles
hal-00682429v1
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Identification de nouveaux gènes cibles des hydrocarbures aromatiques polycycliques dans les macrophages humains en culture primaire par une approche transcriptomique
Lydie Sparfel
,
Marie-Laure Pinel-Marie
,
Magali Boize
,
Serge Koscielny
,
Sophie Desmots
,
et al.
Congrès de la Société de Pharmaco-Toxicologie Cellulaire " Toxicologie prédictive : les voies du futur ", May 2010, Paris, France
Conference papers
hal-00674292v1
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Apports des approches " omiques " pour modéliser la cinétique et les effets de xénobiotiques chez l'homme
Alexandre R.R. Pery
,
Céline Brochot
,
M. Dumas
,
Magali Boize
,
Sophie Desmots
,
et al.
Colloque ARET, Jun 2010, Paris, France
Conference papers
hal-00674296v1
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Effects of endocrine disruptors in adult rats: integrative evaluation from gonadal steroidogenic gene expression profiles to hormonal balance
Nadia Quignot
,
Sophie Desmots
,
Robert Barouki
,
Emmanuel Lemazurier
Society for Endocrinology BES 2011 meeting, Apr 2011, Birmingham, United Kingdom
Conference papers
ineris-00970765v1
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Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcαRI by the environmental contaminant benzo(a)pyrene in human macrophages.
Marie-Laure Pinel-Marie
,
Laetitia Louarn
,
Sophie Desmots
,
Olivier Fardel
,
Lydie Sparfel
Journal articles
istex
hal-00682119v1
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Determination of cis-permethrin, trans-permethrin and associated metabolites in rat blood and organs by gas chromatography–ion trap mass spectrometry
Francois Lestremau
,
Marie-Emilie Willemin
,
Claudine Chatellier
,
Sophie Desmots
,
Céline Brochot
Journal articles
ineris-01710209v1
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Aryl hydrocarbon receptor-dependent induction of the NADPH oxidase subunit NCF1/p47 phox expression leading to priming of human macrophage oxidative burst.
Marie-Laure Pinel-Marie
,
Lydie Sparfel
,
Sophie Desmots
,
Olivier Fardel
Journal articles
istex
hal-00673349v1
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Self-reported parental exposure to pesticide during pregnancy and birth outcomes : The MecoExpo cohort study
Flora Mayhoub
,
Thierry Berton
,
Véronique Bach
,
Karine Tack
,
Caroline Deguines
,
et al.
Journal articles
ineris-01862439v1
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Changes in cellular localization of claudin-11 and P-glycoprotein during rat testis development
Audrey Legendre
,
Sophie Desmots
,
Anthony Lecomte
,
Franck Robidel
,
Olivier Dupont
,
et al.
16. European Workshop on Molecular and Cellular Endocrinology of the Testis (European Testis Workshop; ETW16), May 2010, La Biodola, Italy
Conference papers
ineris-00970643v1
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