OpenRiskNet, an open e-infrastructure to support data sharing, knowledge integration and in silico analysis and modelling in risk assessment - Ineris - Institut national de l'environnement industriel et des risques Access content directly
Conference Papers Year : 2018

OpenRiskNet, an open e-infrastructure to support data sharing, knowledge integration and in silico analysis and modelling in risk assessment

T. Exner
  • Function : Author
J. Dokler
  • Function : Author
D. Bachler
  • Function : Author
Lucian Romeo Farcal
  • Function : Author
Chris Evelo
Egon Willighagen
D. Jennen
  • Function : Author
M. Jabocs
  • Function : Author
P. Doganis
  • Function : Author
H. Sarimveis
  • Function : Author
I. Lynch
  • Function : Author
G. Gkoutos
  • Function : Author
S. Kramer
  • Function : Author
C. Notredame
  • Function : Author
O. Spjuth
  • Function : Author
Paul Jennings
  • Function : Author
T. Dudgeon
  • Function : Author
Barry Hardy
  • Function : Author

Abstract

OpenRiskNet (https://openrisknet.org/) is an EU funded infrastructure project with the main objective to develop an open e-infrastructure providing resources and services to a variety of industries requiring risk assessment, including chemicals, cosmetic ingredients, drugs and nanomaterials. The OpenRiskNet approach is to work on different case studies to test and evaluate requirements to overcome the fragmentation of data and tools and to provide solutions improving the harmonization of data, usability and interoperability of application programming interfaces (APIs) and the deployment into virtual infrastructure. The cases present real-world settings such as systems biology approaches for grouping compounds, read-across applications using chemical and biological similarity, and identifying areas of concern based only on alternative methods approaches. We discuss our progress on the OpenRiskNet goal of harmonizing data and metadata within APIs that can be added to already existing analysis and modeling services and data warehouses. We also demonstrate how these APIs can easily be used towards the generation of full risk assessment workflows either using scripting languages or workflow managers. Finally, we show the first approaches to make these APIs semantically rich by annotating data with human- and computer-readable data schemata. OpenRiskNet has initiated the Associated Partners Programme strengthening the working ties between the OpenRiskNet members and other organizations within the scientific community.

Domains

Toxicology

Dates and versions

ineris-03239330 , version 1 (27-05-2021)

Identifiers

Cite

T. Exner, J. Dokler, D. Bachler, Lucian Romeo Farcal, Chris Evelo, et al.. OpenRiskNet, an open e-infrastructure to support data sharing, knowledge integration and in silico analysis and modelling in risk assessment. 54. Congress of the European Societies of Toxicology (EUROTOX 2018), Sep 2018, Bruxelles, Belgium. pp.S104, ⟨10.1016/j.toxlet.2018.06.617⟩. ⟨ineris-03239330⟩

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