Pulmonary and gastric lead burden assessment for lead-recycling plant workers
Résumé
As a function of PM size (PM10-2.5, PM2.5-1 and PM1) and origin (furnace, refining and channeled emissions), lead toxicity and bioaccessibility assessment were performed in a lead recycling plant using complementary biologic and chemical acellular tests. According to their origin, process PM displays differences in metal contents, granulometry and percentage of inhalable fraction. Lead gastric bioaccessibility was relatively low (maximum 25%) in comparison with previous available studies, though due to their high total lead concentrations, significant metal quantities couldreach the circulatory system. Whatever their origin, finest PM1 particles induced the greatest pro-inflammatory response from human bronchial epithelial cells. Moreover, this biological response was correlated with the acellular DiThioThreitol (DTT) assay, suggesting some biological predictive value for such acellular test.
Domaines
Sciences de l'environnement| Origine | Fichiers produits par l'(les) auteur(s) |
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