%0 Journal Article %T Biodistribution and clearance of instilled carbon nanotubes in rat lung %+ Institut National de l'Environnement Industriel et des Risques (INERIS) %+ Institut de Radioprotection et de Sûreté Nucléaire (IRSN) %+ Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire %+ Hôpital Bichat / Centre d'Investigation Clinique 007 %A Elgrabli, Dan %A Floriani, Magali %A Abella-Gallart, Steve %A Meunier, Laurent %A Gamez, Christelle %A Delalain, Patrice %A Rogerieux, Françoise %A Boczkowski, Jorge %A Lacroix, Ghislaine %< avec comité de lecture %@ 1743-8977 %J Particle and Fibre Toxicology %I BioMed Central %V 5 %N 20 %P NC %8 2008 %D 2008 %R 10.1186/1743-8977-5-20 %M 19068117 %Z Life Sciences [q-bio]/Toxicology %Z Environmental SciencesJournal articles %X Background: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. Methods: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated. Results and conclusion: Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration %G English %L ineris-00963147 %U https://ineris.hal.science/ineris-00963147 %~ SDE %~ INERIS %~ IRSN %~ UNIV-PARIS7 %~ BICHAT %~ GIP-BE %~ UNIV-PARIS