%0 Journal Article %T PLS-QSAR of the adult and developmental toxicity of chemicals to Hydra attenuata %+ Centre de Traitement de l'Informatique Scientifique %+ Institut National de l'Environnement Industriel et des Risques (INERIS) %A Devillers, James %A Chezeau, Aurélie %A Thybaud, Eric %< avec comité de lecture %@ 1062-936X %J SAR and QSAR in Environmental Research %I Taylor & Francis %V 13 %N 7-8 %P 705-712 %8 2002 %D 2002 %R 10.1080/1062936021000043445 %M 12570047 %K GLYCOL ETHERS %K ORGANIC CHEMICALS %K HYDRA ATTENUATA %K AUTOCORRELATION METHOD %K QSAR %K PLS REGRESSIO %Z Life Sciences [q-bio]/Toxicology/Ecotoxicology %Z Environmental SciencesJournal articles %X Autocorrelation descriptors encoding lipophilicity, molar refractivity, the H-bonding acceptor and donor ability of the molecules and also indicator variables were used to describe 30 organic chemicals characterized by their adult and developmental toxicities to Hydra attenuata. A PLS regression analysis was successfully employed to derive a QSAR model allowing the simulation of both endpoints. Comparisons were made with orthogonal regression analysis and different nonlinear regression analyses. %G English %L ineris-00962837 %U https://ineris.hal.science/ineris-00962837 %~ SDE %~ INERIS %~ GIP-BE